Natural materials have been gaining lot of interest in the field of drug delivery because they are readily available, cost effective, eco-friendly, nonirritant, capable of multitude of chemical modifications, potentially degradable and compatible due to their natural origin. The present study was an attempt to evaluate the Hibiscus Esculentus gum (HEG) as a novel sustained release excipient in tablet dosage form. Matrix tablets of Aceclofenac, a model drug, were formulated by direct compression technique. For study, different proportions of HEG (10% to 30% w/w) were selected with respect to total weight of the tablet. The developed matrix tablets were evaluated for thickness, uniformity of weight, hardness, friability, drug content and in-vitro drug release study. The developed matrix tablets were found to have uniform physical appearance, thickness, weight, drug content and adequate hardness. All the formulations developed were found to follow zero order drug release kinetics. The results of in-vitro release revealed that, as the percentage of HEG in the tablet was increased, the drug release from the formulations retarded this suggest that HEG is useful sustained release excipient in the preparation of matrix tablet.
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